陈怀侠教授
  • 作者:佚名    发布日期:2010-05-05    点击率:

     名:陈怀侠

出生年月:19667

职称职务:博士、教授、博士生导师,分析化学研究室主任、支部书记

专业方向:分析化学

办公电话:027-88662747

E-mail hxch@hubu.edu.cn

 

研究领域与兴趣:

1 现代分离技术:样品前处理方法、色谱-质谱分析;

2 环境分析:环境(微)微污染物分析;

3 食品分析:食品农残等毒物分析和食品安全;

4 药物分析:药物(代谢)分析、药物体内过程研究、中药活性成分分离分析。

 

教育与研究经历:

武汉大学分析化学专业本科、硕士和博士研究生毕业。

长期从事复杂样品分离分析科研,主要内容包括:(1)新型(微)萃取介质合成及其应用:分子印迹聚合物、整体柱、纳米磁微粒、新型碳材料、金属有机骨架材料等;(2)生物、食品和环境等实际样品微量及痕量组分分析:药物分析、药物体内过程、食品农残、环境(微)污染物等;教育部入库专家,中国化学学会会员,主持国家自然科学基金、教育部重点基金项目、湖北省自然科学基金、湖北省教育厅重点基金项目和省科技厅科技攻关项目等20多项;发表科研论文100余篇,其中SCI收录78篇。

 

教学情况:

1、主讲课程:主讲分析化学及实验、仪器分析及实验和现代分离科学(本科生和研究生)等课程,教学质量评价优秀,湖北省分析化学资源共享课程负责人。

2、编写出版教材:

1)《仪器分析实验》主编,科学出版社,2017年;

2)《无机及分析化学》副主编,科学出版社,2009年;

3)《无机及分析化学》主审,中国林业出版社,2012年。

3主持教研项目:

1)湖北大学教研项目制药工程专业人才培养平台全方位搭建与实践2017.5-2019.8

2)湖北大学教研项目现代分析化学课程群2016.12-2018.12

3)湖北大学教研项目现代分离科学教材建设2016.12-2018.12

4)湖北大学教学专项建设项目制药工程专业建设2016.6-2020.12

5)湖北省高等学校省级教学研究项目分析化学课程群新体系构建与实践2015.1-2016-12

6)湖北省高等学校省级教学研究项目设计性(研究性)实践教学内容的研究与实践2006.1-2008-12

7)湖北大学教学研究项目分析化学精品课程群建设2011.1-2013.7

4、教研论文:大学化学化工高等教育等刊物发表教研论文26篇。

 

承担项目与课题(10项代表):

1)国家自然科学基金新型微污染物PPCPs及其代谢转化物分布调查和迁移转化规律研究20975030),主持人;

2)国家自然科学基金重点项目确有疗效复方中药痹祺胶囊的药代动力学研究30630075),主要成员;

3)国家自然科学基金重点项目新荧光探针标记磷酸化蛋白的毛细管电泳测定和细胞成像研究20575047),主要成员;

4 教育部科学技术研究重点项目湖北地道药材黄连活性成分代谢及其与血浆蛋白结合研究208090),主持人;

5 湖北省自然科学基金新型微污染物PPCPs及其代谢转化物分析研究2009CDB364),主持人;

6 湖北省科技厅科技攻关项目莨菪烷类生物碱药代动力学药代产物研究2004AA301C106),主持人;

7)湖北省教育厅重点项目湖北省水环境中防晒剂污染分析及自然光降解研究D20120106),主持人;

8 省部共建教育部重点实验室项目中药黄酮类化合物指纹图谱及含量测定研究2005-KL-009),主持人;

9 湖北省中药生物技术重点实验室开放基金中药生物碱活性成分的代谢研究2005CTM001),主持人;

10 湖北大学人才专项基金中药复方药物代谢研究ky2006004),主持人;

 

代表性研究成果(30篇代表作):

(1)  Jianli Zhu, Dongping Chen, Youhong Ai, Xueping Dang, Jianlin Huang, Huaixia Chen*. A dummy molecularly imprinted monolith for selective solid-phase microextraction of vanillin and methyl vanillin prior to their determination by HPLC. Microchim Acta 2017, 184(4):1161-1167.

(2)  X Ma, F Feng, Y Yang, X Dang, J Huang, H Chen*. Magnetic Solid-Phase Extraction of N,N-Diethyl-m-Toluamide From Baby Toilet Water Prior to its HPLC-UV Detection. J Chromatogr Sci 2017, 55 (6): 662-668.

(3)  Di Chen, Xiaoxuan Han, Qi Wang, Liujing Xie, Youhong Ai, Xueping Dang, Jianlin Huang, Huaixia Chen*. Magnetic molecular imprinted polymers for selective extraction and determination of naphthols. Microchim Acta 2017, 184: 3373-3379.

(4)  Bin Sun, Chunpeng Wang, Qi Wang, Ling Chen, Xueping Dang, Jianlin Huang, Huaixia Chen*. Preparation of acryloyl β-cyclodextrin organic polymer monolithic column and its application in solid phase microextraction and HPLC analysis for carbofuran and carbaryl in rice. Food Anal Methods 2017, 10: 3847-3855.

(5)  Yang Yang, Xiaowei Ma, Fan Feng, Xueping Dang, Jianlin Huang, Huaixia Chen*. Magnetic solid-phase extraction of triclosan using core-shell Fe3O4@MIL-100 magnetic nanoparticles, and its determination by HPLC with UV detection. Microchim Acta 2016, 183(8): 2467-2472.

(6)  Bo Wu, Jinxia Li, Huaixia Chen*, Yong Ye. Fate of metronidazole under solar irradiation. Environ Eng Manag J 2016, 15(1): 1003-1008

(7)  Xueping Dang, Chengguo Hu, Huaixia Chen, Jianlin Huang, Dongyun Zheng, Shengshui Hu. Photoelectrochemistry and sensor of NO based on a supramolecular system composed of polyhydroqinone and fullerene. Sensor Actuat B-Chem 2016, 228: 709-715.

(8)  Ning Li, Quanfei Zhu, Yang Yang, Jianlin Huang, Xueping Dang, Huaixia Chen*. A novel dispersive solid-phase extraction method using metal-organic framework MIL-101 as the adsorbent for the analysis of benzophenones in toner. Talanta 2015, 132(15): 713–718.

(9)  Xiaofang Liu, Shu Zhou, Quanfei Zhu, Yong Ye, Huaixia Chen*. Ultra preconcentration of polycyclic aromatic hydrocarbons in smoked bacon by a combination of SPE and DLLME. J Chromatogr Sci 2014, 52(8): 932-937.

(10)          Quanfei Zhu, Chao Ma, Huaixia Chen*, Yaqi Wu, Jianlin Huang. A molecular imprint-coated stirrer bar for selective extraction of caffeine, theobromine and theophylline. Microchim. Acta 2014, 181(3-4): 303-311.

(11)          Ting Yang, Chao Ma, Huaixia Chen*, Yajie Zhang, Xueping Dang, Jianlin Huang. A molecularly imprinted organic-inorganic hybrid monolithic column for selective extraction and high-performance liquid chromatography determination of isoprocarb residues in rice. J Sep Sci 2014, 37: 587–594.

(12)          Xiaofang Liu, Quanfei Zhu, Huaixia Chen, Liuzi Zhou, Xueping Dang, Jianlin Huang. Preparation of 2,4-dichlorophenoxyacetic acid imprinted organic–inorganic hybrid monolithic column and application to selective solid-phase microextraction. J Chromatogr B 2014, (951-952): 32–37.

(13)          Ting Zhang, Chao Ma, Mei Wu, Yong Ye, Huaixia Chen*, Jianlin Huang. Selective microextraction of carbaryl and naproxen using organic-inorganic monolithic columns containing a double molecular imprint. Microchim Acta 2013, 180: 695–702.

(14)          Ting Zhang, Bo Wu, Na Sun, Yong Ye, Huaixia Chen*. Sorption and degradation of wastewater-associated pharmaceuticalsand personal care products in agricultural soils and sediment. Water Sci Technol 2013, 68 (5): 991-998.

(15)          Xiaofang Liu, Na Sun, Quanfei Zhu, Mei Wu, Yong Ye, Huaixia Chen*. Preparation, characterization and application of organic-inorganic hybrid caffeine imprinted monolith. J Chromatogr A 2013, 1304: 10-17.

(16)          Juan Li, Huaixia Chen*, Hui Chen and Yong Ye. Selective determination of trace thiamphenicol in milk and honey by molecularly imprinted polymer monolith microextraction and high-performance liquid chromatography. J Sep Sci 2012, 35 (1): 137–144.

(17)          Shu Zhou, Huaixia Chen*, Bo Wu, Chao Ma, Yong Ye. Sensitive determination of carbamates in fruit and vegetables by a combination of solid-phase extraction and dispersive liquid-liquid microextraction prior to HPLC. Microchim Acta 2012, 176: 419–427.

(18)          Shu Zhou, Bo Wu, Chao Ma, Yong Ye. Huaixia Chen*. Solid-phase extraction followed by dispersive liquid-liquid microextraction for the sensitive determination of carbamates in environmental water by high-performance liquid chromatography. J Liq Chromatogr R T 2012, 35: 1-13.

(19)          Bo Wu, Ting Zhang, Jinxia Li, Yong Ye. Huaixia Chen*. The photodegradation of metronidazole in the presence of coexisting pharmaceuticals. Water Sci Technol 2012, 735-740.

(20)          Na Sun, Shengli Wu, Huaixia Chen*, Daijun Zheng, Junwen Xu, Yong Ye. Determination of sulfamethoxazole in milk using molecularly imprinted polymer monolith microextraction coupled to HPLC. Microchim Acta 2012, 179: 33-40.

(21)          Chao Ma, Hui Chen, Na Sun, Yong Ye, Huaixia Chen*. Preparation of Molecularly Imprinted Polymer Monolith with an Analogue of Thiamphenicol and Application to Selective Solid-Phase Microextraction. Food Anal Methods 2012, 5: 1267–1275.

(22)          Jinfang Zhou, Chao Ma, Shu Zhou, Peili Ma, Fangrong Chen, Yue Qi, Huaixia Chen*. Preparation, evaluation and application of molecularly imprinted solid-phase microextraction monolith for selective extraction of pirimicarb in tomato and pear. J Chromatogr A 2010, 1217: 7478-7483.

(23)          Huaixia Chen*, Jianlin Huang, Juan Li. Characterization of metabolites of worenine in rat biological samples using liquid chromatography–tandem mass spectrometry. J Pharm Biomed Anal 2010, 51: 236-243.

(24)          Huaixia Chen*, Hui Chen, Lei Liao, Jun Ying, and Jianlin Huang. Determination of thiamphenicol in honey by dispersive liquid-liquid microextractionwith high-performance liquid chromatography. J Chromatogr Sci 2010, 48: 450-455.

(25)          Huaixia Chen*, Hui Chen, Jun Ying, Jianlin Huang, Lei Liao. Dispersive liquid-liquid microextraction followed by high-performance liquid chromatography as an efficient and sensitive technique for simultaneous determination of chloramphenicol and thiamphenicol in honey. Anal Chim Acta 2009, 63280-85.

(26)          Huaixia Chen*, Yong Chen, Peng Du, Fengmei Han. Structural elucidation of in vivo and in vitro metabolites of anisodine by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal 2007, 44: 773-778.

(27)          B.Y. Ge, H.X. Chen, F.M. Han, Y. Chen. Identification of Amygdalin and its major metabolites in Rat Urine by LC-MS/MS. J Chromatogr B 2007, 857281-286.

(28)          Mingming Zhu, Fengmei Han, Huaixia Chen, Zhihong Peng, Yong Chen. Identification of palmatine and its metabolites in rat urine by liquid chromatography-tandem mass spectrometry. Rapid Commun Mass Spectrum 2007, 2113:2019-2022. 引用8次(2013.4.7

(29)          Zhihong Peng, Wei Song, Fengmei Han, Huaixia Chen, Mingming Zhu, Yong Chen. Chromatographic tandam mass spectrometric setection of papaverine and its major metabolites in rat urine. Int J Mass Spectrom 2007266: 114-121.

(30)          Huaixia Chen, Yong Chen, Hong Wang, Peng Du, Fengmei Han, Huashan Zhang*. Analysis of scopolamine and its eighteen metabolites in rat urine by Liquid chromatography-tandem mass spectrometry. Talanta 2005, 67/5984-991.

 

 

获奖与荣誉:

中共湖北省委优秀党务工作者

湖北省教学成果一等奖(排名第四);

湖北大学教学成果一等奖(排名第六);

湖北大学优秀党员;

湖北大学教学名师;

湖北大学2009年度和2001年度本科教学质量优秀奖;

湖北大学优秀教师;

湖北大学工会优秀女会员;

学校优秀教案三等奖。